[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:06.08,0:00:09.78,Default,,0000,0000,0000,,(chairman) So, let's welcome Egon, Dialogue: 0,0:00:09.78,0:00:13.48,Default,,0000,0000,0000,,who will describe how he is trying Dialogue: 0,0:00:13.48,0:00:17.58,Default,,0000,0000,0000,,to improve the coverage \Nof chemical compounds in Wikidata. Dialogue: 0,0:00:18.29,0:00:19.68,Default,,0000,0000,0000,,(Egon) Yeah, thank you. Dialogue: 0,0:00:20.69,0:00:22.31,Default,,0000,0000,0000,,So, let's see... Dialogue: 0,0:00:22.68,0:00:24.92,Default,,0000,0000,0000,,Oh, this is not right. Dialogue: 0,0:00:25.88,0:00:26.90,Default,,0000,0000,0000,,Sorry. Dialogue: 0,0:00:31.75,0:00:33.32,Default,,0000,0000,0000,,They put the wrong slide deck. Dialogue: 0,0:00:40.18,0:00:42.64,Default,,0000,0000,0000,,(person 1) The one was better than--\N(person 2) [inaudible] Dialogue: 0,0:00:42.64,0:00:44.14,Default,,0000,0000,0000,,(person 1) (laughs) Dialogue: 0,0:00:49.06,0:00:50.28,Default,,0000,0000,0000,,How about this? Dialogue: 0,0:00:52.63,0:00:54.76,Default,,0000,0000,0000,,This one actually says WikidataCon. Dialogue: 0,0:00:56.54,0:00:58.48,Default,,0000,0000,0000,,Slightly different slides. Dialogue: 0,0:01:00.17,0:01:05.56,Default,,0000,0000,0000,,Okay, so yeah, coverage and correctness, Dialogue: 0,0:01:05.56,0:01:08.09,Default,,0000,0000,0000,,accuracy, quality, if you like. Dialogue: 0,0:01:09.42,0:01:11.59,Default,,0000,0000,0000,,And the other thing here Dialogue: 0,0:01:11.59,0:01:14.63,Default,,0000,0000,0000,,is what makes it different \Nfrom some of the other things Dialogue: 0,0:01:14.63,0:01:17.28,Default,,0000,0000,0000,,that we've seen at the WikidataCon Dialogue: 0,0:01:17.28,0:01:20.16,Default,,0000,0000,0000,,is how I do this quality, Dialogue: 0,0:01:20.16,0:01:21.91,Default,,0000,0000,0000,,and the coverage, actually. Dialogue: 0,0:01:21.91,0:01:25.22,Default,,0000,0000,0000,,So I'm actually taking advantage here\Nof my background, Dialogue: 0,0:01:25.22,0:01:27.17,Default,,0000,0000,0000,,which is in cheminformatics, Dialogue: 0,0:01:27.17,0:01:30.11,Default,,0000,0000,0000,,which is something \Nthat we use in our research. Dialogue: 0,0:01:30.33,0:01:32.99,Default,,0000,0000,0000,,And cheminformatics Dialogue: 0,0:01:32.99,0:01:35.12,Default,,0000,0000,0000,,is a way to understanding \Nthe chemical structures, Dialogue: 0,0:01:35.12,0:01:36.58,Default,,0000,0000,0000,,what we will see in a moment. Dialogue: 0,0:01:36.58,0:01:39.84,Default,,0000,0000,0000,,We can do things that we cannot do \Nwith the regular toolsets Dialogue: 0,0:01:39.84,0:01:43.52,Default,,0000,0000,0000,,that we have, like Shape Expressions,\Nquality constraints and sorts. Dialogue: 0,0:01:45.86,0:01:49.20,Default,,0000,0000,0000,,Now, one of the interesting\Nthings of chemistry Dialogue: 0,0:01:49.50,0:01:51.73,Default,,0000,0000,0000,,is that chemical structures, Dialogue: 0,0:01:52.85,0:01:55.47,Default,,0000,0000,0000,,are sometimes the same,\Nsometimes not the same, Dialogue: 0,0:01:55.47,0:01:57.68,Default,,0000,0000,0000,,depending on what you want to know. Dialogue: 0,0:01:58.10,0:02:00.64,Default,,0000,0000,0000,,And this slide reflects that a bit, Dialogue: 0,0:02:00.64,0:02:05.01,Default,,0000,0000,0000,,and what we see here \Nis biologically the same compounds Dialogue: 0,0:02:05.01,0:02:07.94,Default,,0000,0000,0000,,but chemically two different compounds. Dialogue: 0,0:02:08.50,0:02:11.91,Default,,0000,0000,0000,,But at biological levels \Nwith the [inaudible], Dialogue: 0,0:02:11.91,0:02:13.58,Default,,0000,0000,0000,,they are in equilibrium, Dialogue: 0,0:02:13.58,0:02:16.48,Default,,0000,0000,0000,,and you will not be able \Nto really distinguish between them, Dialogue: 0,0:02:16.74,0:02:19.91,Default,,0000,0000,0000,,unless you're looking \Nfor a particular type of biology Dialogue: 0,0:02:19.91,0:02:21.91,Default,,0000,0000,0000,,like reaction mechanisms. Dialogue: 0,0:02:23.21,0:02:26.98,Default,,0000,0000,0000,,Another interesting thing \Nabout Wikidata and Wikipedia Dialogue: 0,0:02:26.98,0:02:31.55,Default,,0000,0000,0000,,is that we have things \Nlike long-chain fatty acids, Dialogue: 0,0:02:31.55,0:02:34.54,Default,,0000,0000,0000,,chemical concepts\Nwhich are not a specific compound Dialogue: 0,0:02:34.54,0:02:36.75,Default,,0000,0000,0000,,but actually a class of compounds. Dialogue: 0,0:02:37.35,0:02:42.87,Default,,0000,0000,0000,,Now, this class can be based \Non similar features in the molecules, Dialogue: 0,0:02:42.87,0:02:46.14,Default,,0000,0000,0000,,so like in the case \Nof the long-chain fatty acids-- Dialogue: 0,0:02:46.14,0:02:51.78,Default,,0000,0000,0000,,they all have a long-chain fatty\Nand an acid group. Dialogue: 0,0:02:51.78,0:02:54.10,Default,,0000,0000,0000,,In other cases, there are the classes Dialogue: 0,0:02:54.10,0:02:57.12,Default,,0000,0000,0000,,based more\Non the biological functionality, Dialogue: 0,0:02:57.12,0:03:00.44,Default,,0000,0000,0000,,like a certain type of inhibitor,\Nlike an ACE inhibitor. Dialogue: 0,0:03:01.76,0:03:05.63,Default,,0000,0000,0000,,And this introduces \Na lot of interesting things, Dialogue: 0,0:03:05.63,0:03:09.65,Default,,0000,0000,0000,,partly because of this close link \Nwith Wikipedias. Dialogue: 0,0:03:10.27,0:03:12.60,Default,,0000,0000,0000,,And one of the things that we see Dialogue: 0,0:03:12.60,0:03:17.98,Default,,0000,0000,0000,,is that Wikipedia may have a chembox \Nfor a particular compound Dialogue: 0,0:03:17.98,0:03:20.47,Default,,0000,0000,0000,,bur actually be about a compound class, Dialogue: 0,0:03:20.47,0:03:25.32,Default,,0000,0000,0000,,resulting to a slightly different concept Dialogue: 0,0:03:25.32,0:03:27.42,Default,,0000,0000,0000,,of what the two things \Nare actually meaning Dialogue: 0,0:03:27.42,0:03:29.99,Default,,0000,0000,0000,,and the sitelink being more complicated. Dialogue: 0,0:03:33.19,0:03:38.90,Default,,0000,0000,0000,,We need this \Nfor understanding the biology. Dialogue: 0,0:03:38.90,0:03:42.92,Default,,0000,0000,0000,,So the research in our group \Nis understanding the living cell. Dialogue: 0,0:03:43.44,0:03:47.03,Default,,0000,0000,0000,,The system's biology here \Ndescribed in the biological process Dialogue: 0,0:03:47.03,0:03:50.54,Default,,0000,0000,0000,,is we have a pathway database \Nfor that--WikiPathways, Dialogue: 0,0:03:50.54,0:03:54.02,Default,,0000,0000,0000,,and if we look at the chemistry in there\Nof the small molecules, Dialogue: 0,0:03:55.66,0:03:59.18,Default,,0000,0000,0000,,the chemistry is sometimes \Ndescribed in a lot of details, Dialogue: 0,0:03:59.18,0:04:00.74,Default,,0000,0000,0000,,sometimes in less detail, Dialogue: 0,0:04:00.74,0:04:04.22,Default,,0000,0000,0000,,pretty much like this Wikipedia\NWikidata link that we just had Dialogue: 0,0:04:04.22,0:04:08.43,Default,,0000,0000,0000,,resulting in basically links\Nto a lot of different databases Dialogue: 0,0:04:08.43,0:04:10.42,Default,,0000,0000,0000,,with slightly different focuses. Dialogue: 0,0:04:10.89,0:04:15.35,Default,,0000,0000,0000,,Some databases like LIPID MAPS\Nand the Human Metabolome Database, Dialogue: 0,0:04:15.35,0:04:17.58,Default,,0000,0000,0000,,they are very much focused on the biology, Dialogue: 0,0:04:17.58,0:04:20.74,Default,,0000,0000,0000,,whereas a database like ChEBI, Dialogue: 0,0:04:20.74,0:04:24.62,Default,,0000,0000,0000,,that's very much focused \Non the chemical entities. Dialogue: 0,0:04:26.24,0:04:27.90,Default,,0000,0000,0000,,So we try to breach that, Dialogue: 0,0:04:27.90,0:04:33.45,Default,,0000,0000,0000,,and that two-three years ago gave us\Na very interesting insight Dialogue: 0,0:04:33.45,0:04:35.87,Default,,0000,0000,0000,,that if you look at the lines here Dialogue: 0,0:04:35.87,0:04:40.15,Default,,0000,0000,0000,,where in blue we have the total number \Nof the small molecules Dialogue: 0,0:04:40.15,0:04:41.88,Default,,0000,0000,0000,,we have in these Pathways Dialogue: 0,0:04:41.88,0:04:44.90,Default,,0000,0000,0000,,and the numbers in red \Nthat we can match to that, Dialogue: 0,0:04:44.90,0:04:48.40,Default,,0000,0000,0000,,there is this gap, and this gap \Nis complicated chemistry. Dialogue: 0,0:04:49.27,0:04:52.43,Default,,0000,0000,0000,,Also, poignantly, things\Nmissing in Wikidata. Dialogue: 0,0:04:52.78,0:04:55.33,Default,,0000,0000,0000,,So therefore the need \Nfor date completeness Dialogue: 0,0:04:55.33,0:04:57.72,Default,,0000,0000,0000,,and the data quality. Dialogue: 0,0:05:00.49,0:05:02.18,Default,,0000,0000,0000,,And here we have an example. Dialogue: 0,0:05:02.18,0:05:05.64,Default,,0000,0000,0000,,This is actually \Na curation report of yesterday, Dialogue: 0,0:05:05.64,0:05:08.39,Default,,0000,0000,0000,,and these are still things \Nthat we have in Pathways Dialogue: 0,0:05:08.39,0:05:13.67,Default,,0000,0000,0000,,but that we do not know \Nwhat the equivalent thing is in Wikidata. Dialogue: 0,0:05:14.08,0:05:17.53,Default,,0000,0000,0000,,And one of the things here\Nthat I'm picking out here Dialogue: 0,0:05:17.53,0:05:18.93,Default,,0000,0000,0000,,is strigolactone. Dialogue: 0,0:05:19.12,0:05:21.02,Default,,0000,0000,0000,,And this is a class of compounds. Dialogue: 0,0:05:22.03,0:05:27.08,Default,,0000,0000,0000,,So we have that in one of our Pathways,\Nthis particular Pathway over there. Dialogue: 0,0:05:29.21,0:05:32.17,Default,,0000,0000,0000,,So you start matching this \Nto Wikidata and Wikipedia, Dialogue: 0,0:05:32.17,0:05:35.39,Default,,0000,0000,0000,,and to actually use\Nfor this compound Wikipedia page Dialogue: 0,0:05:35.98,0:05:38.87,Default,,0000,0000,0000,,with these six structures-- Dialogue: 0,0:05:38.87,0:05:42.10,Default,,0000,0000,0000,,images, name, no links, nothing. Dialogue: 0,0:05:42.10,0:05:43.17,Default,,0000,0000,0000,,Nothing in Wikipedia, Dialogue: 0,0:05:43.17,0:05:45.56,Default,,0000,0000,0000,,just this information, \Nnot machine-readable. Dialogue: 0,0:05:47.94,0:05:53.02,Default,,0000,0000,0000,,So based on the name, \NI can actually find three out of the six Dialogue: 0,0:05:53.02,0:05:54.87,Default,,0000,0000,0000,,of these compounds in Wikidata, Dialogue: 0,0:05:54.87,0:05:56.64,Default,,0000,0000,0000,,not linked, not classified. Dialogue: 0,0:05:57.25,0:06:00.43,Default,,0000,0000,0000,,So if we look at the class \Nof strigolactones, Dialogue: 0,0:06:00.43,0:06:03.02,Default,,0000,0000,0000,,of which these six are examples, Dialogue: 0,0:06:03.02,0:06:05.30,Default,,0000,0000,0000,,Wikidata did not give us anything. Dialogue: 0,0:06:05.30,0:06:08.07,Default,,0000,0000,0000,,So that's the kind of curation\Nthat I'm interested in. Dialogue: 0,0:06:09.17,0:06:12.90,Default,,0000,0000,0000,,On the right here--\Nthat page is actually pretty much empty, Dialogue: 0,0:06:12.90,0:06:17.18,Default,,0000,0000,0000,,but it's exactly what Scholia is showing\Nfor this class of chemical compounds. Dialogue: 0,0:06:18.32,0:06:22.76,Default,,0000,0000,0000,,So Scholia is one of the tools \Nthat I've been using to do this curation. Dialogue: 0,0:06:26.34,0:06:30.55,Default,,0000,0000,0000,,This missing classification\Nis a bit of information Dialogue: 0,0:06:30.55,0:06:32.06,Default,,0000,0000,0000,,missing in Wikidata, Dialogue: 0,0:06:32.06,0:06:34.80,Default,,0000,0000,0000,,but we can add this classification, Dialogue: 0,0:06:34.80,0:06:36.96,Default,,0000,0000,0000,,and we can retrieve that \Nfrom some sources. Dialogue: 0,0:06:36.96,0:06:38.69,Default,,0000,0000,0000,,We will see with LIPID MAPS later, Dialogue: 0,0:06:38.69,0:06:41.16,Default,,0000,0000,0000,,we can automate \Nadding these missing links, Dialogue: 0,0:06:41.66,0:06:44.37,Default,,0000,0000,0000,,if we understand the chemistry. Dialogue: 0,0:06:46.27,0:06:50.55,Default,,0000,0000,0000,,So this diagram over here--\Nwe have fatty acid over there again Dialogue: 0,0:06:50.55,0:06:54.05,Default,,0000,0000,0000,,and the long-chain fatty acid over here Dialogue: 0,0:06:54.05,0:06:56.67,Default,,0000,0000,0000,,that we saw on one\Nof the previous slides-- Dialogue: 0,0:06:56.67,0:07:00.100,Default,,0000,0000,0000,,very long-chain fatty acids \Nand a number of other fatty acids. Dialogue: 0,0:07:01.34,0:07:04.50,Default,,0000,0000,0000,,This kind of information helps us see Dialogue: 0,0:07:04.50,0:07:09.32,Default,,0000,0000,0000,,a [inaudible] of the chemistry \Nin Wikidata. Dialogue: 0,0:07:10.35,0:07:13.54,Default,,0000,0000,0000,,Scholia can visualize the 2D structure, Dialogue: 0,0:07:13.54,0:07:15.100,Default,,0000,0000,0000,,and this thing is actually \Nautomatically generated Dialogue: 0,0:07:15.100,0:07:18.70,Default,,0000,0000,0000,,from the chemical structure in Wikidata Dialogue: 0,0:07:18.95,0:07:22.20,Default,,0000,0000,0000,,on the fly creating \Nin the Scalable Vector Graphics. Dialogue: 0,0:07:22.73,0:07:23.86,Default,,0000,0000,0000,,(coughing) Dialogue: 0,0:07:24.53,0:07:25.56,Default,,0000,0000,0000,,Sorry. Dialogue: 0,0:07:25.56,0:07:28.15,Default,,0000,0000,0000,,With the stereochemistry annotation there Dialogue: 0,0:07:28.15,0:07:32.60,Default,,0000,0000,0000,,to help the chemist see \Nthe completeness of the data Dialogue: 0,0:07:32.60,0:07:35.82,Default,,0000,0000,0000,,because also the stereochemistry \Nmight be missing. Dialogue: 0,0:07:36.45,0:07:40.40,Default,,0000,0000,0000,,We also get an overview on Scholia \Nof related compounds Dialogue: 0,0:07:40.40,0:07:41.87,Default,,0000,0000,0000,,based on the InChIKey, Dialogue: 0,0:07:41.87,0:07:45.66,Default,,0000,0000,0000,,where the first block basically indicates\Nhow the atoms are connected Dialogue: 0,0:07:45.90,0:07:50.32,Default,,0000,0000,0000,,and the second column \Nindicates things like stereochemistry Dialogue: 0,0:07:50.32,0:07:53.84,Default,,0000,0000,0000,,and things like \Nwhich isotopes are in there, Dialogue: 0,0:07:54.33,0:07:57.33,Default,,0000,0000,0000,,for example C11 instead of C12 Dialogue: 0,0:07:57.33,0:08:01.97,Default,,0000,0000,0000,,or C13 instead of C12. Dialogue: 0,0:08:03.44,0:08:06.46,Default,,0000,0000,0000,,The last number \Nof the last letter over here Dialogue: 0,0:08:06.46,0:08:08.67,Default,,0000,0000,0000,,actually indicates the charge, Dialogue: 0,0:08:08.67,0:08:13.87,Default,,0000,0000,0000,,so that's the example that we saw earlier\Nbetween the citric acid and the citrate, Dialogue: 0,0:08:14.49,0:08:16.64,Default,,0000,0000,0000,,or was it the acetic acid and the acetate? Dialogue: 0,0:08:20.50,0:08:23.09,Default,,0000,0000,0000,,By putting in a bit of the main knowledge, Dialogue: 0,0:08:23.09,0:08:27.71,Default,,0000,0000,0000,,we can do a lot more... making sense \Nof what we have in Wikidata. Dialogue: 0,0:08:29.46,0:08:32.64,Default,,0000,0000,0000,,A bit more about Scholia Dialogue: 0,0:08:32.64,0:08:36.37,Default,,0000,0000,0000,,is that about data completeness \Nwith the physical and chemical properties, Dialogue: 0,0:08:36.37,0:08:40.07,Default,,0000,0000,0000,,the literature, those are whole things \Nthat we want to have access to. Dialogue: 0,0:08:40.07,0:08:45.32,Default,,0000,0000,0000,,But it only works if we can find \Nthe right chemical in Wikidata. Dialogue: 0,0:08:48.90,0:08:52.47,Default,,0000,0000,0000,,We started using Wikidata \Nin a number of our projects, Dialogue: 0,0:08:52.47,0:08:54.68,Default,,0000,0000,0000,,so WikiPathways was one of them. Dialogue: 0,0:08:54.68,0:08:56.04,Default,,0000,0000,0000,,This is another project Dialogue: 0,0:08:56.04,0:08:59.57,Default,,0000,0000,0000,,in the area of the nanosafety, \Nrisk assessment, Dialogue: 0,0:08:59.57,0:09:02.73,Default,,0000,0000,0000,,where they use OECD testing guidelines Dialogue: 0,0:09:02.73,0:09:07.66,Default,,0000,0000,0000,,and using Wikidata here \Nto make an overview of the experiments. Dialogue: 0,0:09:07.66,0:09:11.76,Default,,0000,0000,0000,,And this means that we can now\Nactually start annotating articles Dialogue: 0,0:09:11.76,0:09:14.44,Default,,0000,0000,0000,,where these protocols have been used. Dialogue: 0,0:09:15.66,0:09:20.39,Default,,0000,0000,0000,,And in this way, we get a better insight \Nin the quality of literature as well. Dialogue: 0,0:09:20.90,0:09:23.74,Default,,0000,0000,0000,,We get to see which DDTs Dialogue: 0,0:09:23.74,0:09:27.27,Default,,0000,0000,0000,,are well tested, established \Nexperimental methods Dialogue: 0,0:09:27.27,0:09:32.19,Default,,0000,0000,0000,,and an indication of how good the data is \Nthat came out of that. Dialogue: 0,0:09:35.30,0:09:38.20,Default,,0000,0000,0000,,Another example--this is nanomaterials, Dialogue: 0,0:09:38.20,0:09:39.92,Default,,0000,0000,0000,,specific nanomaterials, Dialogue: 0,0:09:40.70,0:09:43.40,Default,,0000,0000,0000,,where there is a unique code-- \Nwe've added that-- Dialogue: 0,0:09:43.40,0:09:45.28,Default,,0000,0000,0000,,with the same purpose of being able Dialogue: 0,0:09:45.28,0:09:48.01,Default,,0000,0000,0000,,to track down literature \Nabout these nanomaterials. Dialogue: 0,0:09:48.66,0:09:51.91,Default,,0000,0000,0000,,But, again, we need exact descriptions. Dialogue: 0,0:09:53.10,0:09:56.24,Default,,0000,0000,0000,,Now, this is \Nthe LIPID MAPS classification, Dialogue: 0,0:09:56.24,0:09:58.01,Default,,0000,0000,0000,,and here we see an interesting thing, Dialogue: 0,0:09:58.01,0:10:01.99,Default,,0000,0000,0000,,and this has shown up \Nin some of the presentations, Dialogue: 0,0:10:02.88,0:10:04.24,Default,,0000,0000,0000,,elsewhere as well. Dialogue: 0,0:10:04.24,0:10:08.11,Default,,0000,0000,0000,,This idea that some of the things \Nthat we have in Wikidata Dialogue: 0,0:10:08.11,0:10:10.31,Default,,0000,0000,0000,,is not always matching the sources. Dialogue: 0,0:10:10.31,0:10:12.06,Default,,0000,0000,0000,,So different ontological models, Dialogue: 0,0:10:12.06,0:10:16.04,Default,,0000,0000,0000,,different ideas \Nof what a particular thing means. Dialogue: 0,0:10:16.22,0:10:20.96,Default,,0000,0000,0000,,And so, if we look at the LIPID MAPS,\Nwe have a lipid in the middle Dialogue: 0,0:10:20.96,0:10:22.74,Default,,0000,0000,0000,,and then a number of classes, Dialogue: 0,0:10:22.74,0:10:25.02,Default,,0000,0000,0000,,and many of these are in Wikidata. Dialogue: 0,0:10:25.45,0:10:30.53,Default,,0000,0000,0000,,But here, around actually \Nfatty acids or fatty acyls, Dialogue: 0,0:10:30.86,0:10:33.19,Default,,0000,0000,0000,,that's where there is a mismatch Dialogue: 0,0:10:33.47,0:10:37.29,Default,,0000,0000,0000,,causing something that should be \Nactually purely hierarchical, Dialogue: 0,0:10:37.29,0:10:41.07,Default,,0000,0000,0000,,actually it started to show \Nsome loops over there, Dialogue: 0,0:10:41.50,0:10:46.19,Default,,0000,0000,0000,,the mismatch of two representations \Nof a lipid chemistry. Dialogue: 0,0:10:48.64,0:10:51.55,Default,,0000,0000,0000,,Now, the goal of this work\Nis not so much to reconcile this Dialogue: 0,0:10:51.55,0:10:53.24,Default,,0000,0000,0000,,but to visualize it Dialogue: 0,0:10:53.24,0:10:55.81,Default,,0000,0000,0000,,so that we can understand \Nwhat is going on Dialogue: 0,0:10:55.81,0:10:58.88,Default,,0000,0000,0000,,and correct things \Nthat are actually clearly wrong. Dialogue: 0,0:11:06.44,0:11:09.62,Default,,0000,0000,0000,,The interesting about LIPID MAPS \Nis actually that the classification Dialogue: 0,0:11:10.10,0:11:12.85,Default,,0000,0000,0000,,is indicated in the external identifier. Dialogue: 0,0:11:12.85,0:11:14.60,Default,,0000,0000,0000,,So one of the things \Nthat we've been using Dialogue: 0,0:11:14.60,0:11:18.84,Default,,0000,0000,0000,,is these external numbers\Nto make this automatic classification Dialogue: 0,0:11:18.84,0:11:22.42,Default,,0000,0000,0000,,because everything \Nthat starts with an LMFA05 Dialogue: 0,0:11:22.60,0:11:25.91,Default,,0000,0000,0000,,is actually a fatty alcohol. Dialogue: 0,0:11:26.24,0:11:28.42,Default,,0000,0000,0000,,So I can translate that \Ninto Quickstatements, Dialogue: 0,0:11:28.42,0:11:29.98,Default,,0000,0000,0000,,push that into Quickstatements Dialogue: 0,0:11:29.98,0:11:32.99,Default,,0000,0000,0000,,and get that annotated in Wikidata. Dialogue: 0,0:11:40.13,0:11:44.22,Default,,0000,0000,0000,,This slide is just reflecting \Nthe advantage for LIPID MAPS here Dialogue: 0,0:11:44.22,0:11:46.36,Default,,0000,0000,0000,,which been collaborating with them Dialogue: 0,0:11:46.36,0:11:50.11,Default,,0000,0000,0000,,because they get a lot of data\Nout of Wikidata as well, Dialogue: 0,0:11:50.28,0:11:54.79,Default,,0000,0000,0000,,which we can cross-reference, \Nwhich we can compare if it's correct. Dialogue: 0,0:11:55.07,0:11:57.97,Default,,0000,0000,0000,,LIPID MAPS is a quite curated database Dialogue: 0,0:11:58.44,0:12:02.28,Default,,0000,0000,0000,,but like everyone actually having trouble Dialogue: 0,0:12:02.28,0:12:04.75,Default,,0000,0000,0000,,with access to literature, Dialogue: 0,0:12:04.75,0:12:07.86,Default,,0000,0000,0000,,the demand of literature \Nand filtering the literature, Dialogue: 0,0:12:07.86,0:12:10.10,Default,,0000,0000,0000,,getting to the right articles. Dialogue: 0,0:12:12.63,0:12:15.13,Default,,0000,0000,0000,,Shape Expressions is probably \Nsomething that you've seen. Dialogue: 0,0:12:15.13,0:12:18.55,Default,,0000,0000,0000,,We have a few of them for chemistry now. Dialogue: 0,0:12:18.55,0:12:21.12,Default,,0000,0000,0000,,This is the example for racemic mixture. Dialogue: 0,0:12:21.12,0:12:26.24,Default,,0000,0000,0000,,In a case of racemic mixture,\Nyou want to have two parts in there. Dialogue: 0,0:12:26.24,0:12:27.36,Default,,0000,0000,0000,,It's a mixture, Dialogue: 0,0:12:27.36,0:12:30.66,Default,,0000,0000,0000,,so at least two chemical entities \Nneed to be in there. Dialogue: 0,0:12:31.01,0:12:35.56,Default,,0000,0000,0000,,Moreover, each of the [inaudible] parts\Nhas to be a chemical compound. Dialogue: 0,0:12:35.56,0:12:41.31,Default,,0000,0000,0000,,This is another level of a way\Nwe can curate the content. Dialogue: 0,0:12:41.81,0:12:43.76,Default,,0000,0000,0000,,There have to be more of them. Dialogue: 0,0:12:43.76,0:12:47.78,Default,,0000,0000,0000,,We have quite a few \Ndifferent concepts in Wikidata Dialogue: 0,0:12:47.78,0:12:49.92,Default,,0000,0000,0000,,like groups of co-compounds. Dialogue: 0,0:12:50.51,0:12:54.71,Default,,0000,0000,0000,,There is a class that is \Nof structurally similar compounds, etc. Dialogue: 0,0:12:57.32,0:13:00.53,Default,,0000,0000,0000,,If you run a query like this,\Nthis case for the other one, Dialogue: 0,0:13:00.53,0:13:04.24,Default,,0000,0000,0000,,other schema that we have\Nfor chemical elements, Dialogue: 0,0:13:04.24,0:13:07.06,Default,,0000,0000,0000,,you can do the same thing-- \Nyou can run it on a single item Dialogue: 0,0:13:07.06,0:13:10.40,Default,,0000,0000,0000,,or you can run that on everything \Nthat is a chemical element. Dialogue: 0,0:13:10.40,0:13:13.80,Default,,0000,0000,0000,,This is something \Nthat I can very much recommend Dialogue: 0,0:13:13.80,0:13:16.75,Default,,0000,0000,0000,,having a look at \Nif you have not done so already. Dialogue: 0,0:13:17.88,0:13:21.55,Default,,0000,0000,0000,,Now, if we go to the automation of things, Dialogue: 0,0:13:22.17,0:13:26.03,Default,,0000,0000,0000,,here I'm using a tool called Bioclipse. Dialogue: 0,0:13:26.03,0:13:29.22,Default,,0000,0000,0000,,This is something that we worked on\Nsome time ten years ago. Dialogue: 0,0:13:29.22,0:13:32.25,Default,,0000,0000,0000,,It's a platform \Nfor chemistry and biology, Dialogue: 0,0:13:32.25,0:13:34.65,Default,,0000,0000,0000,,or cheminformatics and bioinformatics. Dialogue: 0,0:13:34.65,0:13:36.75,Default,,0000,0000,0000,,aimed at automating things, Dialogue: 0,0:13:39.51,0:13:41.45,Default,,0000,0000,0000,,including visualizations and sorts. Dialogue: 0,0:13:41.45,0:13:45.38,Default,,0000,0000,0000,,But I've taken that now \Nand developed a number of scripts Dialogue: 0,0:13:45.38,0:13:47.34,Default,,0000,0000,0000,,that I can actually run \Non the command line, Dialogue: 0,0:13:47.34,0:13:50.76,Default,,0000,0000,0000,,which makes it easier to automate things,\Nas we will see in a moment, Dialogue: 0,0:13:50.76,0:13:52.19,Default,,0000,0000,0000,,and doing all sort of things, Dialogue: 0,0:13:52.19,0:13:55.96,Default,,0000,0000,0000,,for example, the classification \Naccording to the LIPID MAP identifiers, Dialogue: 0,0:13:56.19,0:14:01.72,Default,,0000,0000,0000,,that's the scripts all available \Nfrom the GitHub repository here. Dialogue: 0,0:14:02.67,0:14:05.70,Default,,0000,0000,0000,,And typically, I have them\Ncreate Quickstatements Dialogue: 0,0:14:05.70,0:14:08.99,Default,,0000,0000,0000,,because that gets me \Nan additional check step Dialogue: 0,0:14:08.99,0:14:13.87,Default,,0000,0000,0000,,after I created the Quickstatements \Nand see what does data actually look like. Dialogue: 0,0:14:15.98,0:14:18.71,Default,,0000,0000,0000,,Annotation of main subjects. Dialogue: 0,0:14:18.71,0:14:23.14,Default,,0000,0000,0000,,This one is my script too, \Nstarting from SMILES Dialogue: 0,0:14:23.14,0:14:27.47,Default,,0000,0000,0000,,to actually add chemical compounds\Nthat are not in Wikidata yet, Dialogue: 0,0:14:27.47,0:14:28.82,Default,,0000,0000,0000,,which happens a lot. Dialogue: 0,0:14:29.68,0:14:34.39,Default,,0000,0000,0000,,So three or four weeks ago \NI added something like 500 compounds Dialogue: 0,0:14:34.39,0:14:36.36,Default,,0000,0000,0000,,which our project was looking into Dialogue: 0,0:14:36.36,0:14:41.51,Default,,0000,0000,0000,,because these are \Nvolatile compounds in oils. Dialogue: 0,0:14:44.61,0:14:47.13,Default,,0000,0000,0000,,This script adds the compounds. Dialogue: 0,0:14:47.13,0:14:51.37,Default,,0000,0000,0000,,They will later on add the annotation \Nof which pieces that compound comes from Dialogue: 0,0:14:51.37,0:14:52.87,Default,,0000,0000,0000,,and what the properties are. Dialogue: 0,0:14:55.91,0:14:59.01,Default,,0000,0000,0000,,Bioclipse itself is based \Non the Chemistry Development Kit Dialogue: 0,0:14:59.88,0:15:01.87,Default,,0000,0000,0000,,and a few other libraries. Dialogue: 0,0:15:01.87,0:15:04.72,Default,,0000,0000,0000,,This allows me to do the chemistry. Dialogue: 0,0:15:04.72,0:15:07.97,Default,,0000,0000,0000,,And this is a very well-validated toolkit. Dialogue: 0,0:15:07.97,0:15:11.65,Default,,0000,0000,0000,,The SMILES part has been done \Nby John Mayfield. Dialogue: 0,0:15:11.65,0:15:17.10,Default,,0000,0000,0000,,I have done a lot of validation \Nagainst other tools. Dialogue: 0,0:15:17.52,0:15:20.67,Default,,0000,0000,0000,,And the quality \Nis actually really high now, Dialogue: 0,0:15:21.16,0:15:26.33,Default,,0000,0000,0000,,comparable or in some cases even better \Nof commercial cheminformatics tools. Dialogue: 0,0:15:26.33,0:15:29.28,Default,,0000,0000,0000,,It has given me a lot of reassurance Dialogue: 0,0:15:29.28,0:15:34.92,Default,,0000,0000,0000,,that the quality checking that we do \Nwith this tool on Wikidata Dialogue: 0,0:15:34.92,0:15:37.31,Default,,0000,0000,0000,,is giving interesting results. Dialogue: 0,0:15:38.20,0:15:40.43,Default,,0000,0000,0000,,This is the Quickstatements. Dialogue: 0,0:15:40.43,0:15:43.28,Default,,0000,0000,0000,,Quickstatements\Nis Magnus' work, of course. Dialogue: 0,0:15:44.38,0:15:48.09,Default,,0000,0000,0000,,What happens if we take the SMILES,\Nit calculates the InChI, Dialogue: 0,0:15:48.09,0:15:52.24,Default,,0000,0000,0000,,and the InChIKey, it even looks up \Nbased on the InChIKey, Dialogue: 0,0:15:52.24,0:15:54.20,Default,,0000,0000,0000,,if there is a PubChem identifier Dialogue: 0,0:15:54.20,0:15:58.61,Default,,0000,0000,0000,,that uses the InChIKey, \Nthe PubChem identifier, Dialogue: 0,0:15:58.61,0:16:01.26,Default,,0000,0000,0000,,to see if this compound \Nalready is in Wikidata. Dialogue: 0,0:16:01.26,0:16:03.78,Default,,0000,0000,0000,,And only if it's not already there, Dialogue: 0,0:16:03.78,0:16:06.94,Default,,0000,0000,0000,,then it will actually create\Na CREATE statement. Dialogue: 0,0:16:09.33,0:16:12.82,Default,,0000,0000,0000,,A bit of automatic classification\Nhere is an option. Dialogue: 0,0:16:12.82,0:16:15.16,Default,,0000,0000,0000,,So if I'm adding a class of compounds, Dialogue: 0,0:16:15.16,0:16:17.98,Default,,0000,0000,0000,,I can automatically indicate \Nwhat these are all... Dialogue: 0,0:16:17.98,0:16:19.97,Default,,0000,0000,0000,,this type of compounds, Dialogue: 0,0:16:19.97,0:16:22.60,Default,,0000,0000,0000,,and I can also indicate, if needed, Dialogue: 0,0:16:22.60,0:16:25.21,Default,,0000,0000,0000,,if there is a particular article\Nwhere I got this information Dialogue: 0,0:16:25.21,0:16:27.71,Default,,0000,0000,0000,,from automatically adding references. Dialogue: 0,0:16:29.84,0:16:32.80,Default,,0000,0000,0000,,Well, this is what \Nthe Quickstatements output looks like Dialogue: 0,0:16:32.80,0:16:35.51,Default,,0000,0000,0000,,for the annotation of main subjects. Dialogue: 0,0:16:36.28,0:16:38.15,Default,,0000,0000,0000,,You've probably seen that as well. Dialogue: 0,0:16:40.65,0:16:42.82,Default,,0000,0000,0000,,A newer thing that I started doing Dialogue: 0,0:16:42.82,0:16:46.00,Default,,0000,0000,0000,,is actually doing reasoning \Non the data in Wikidata. Dialogue: 0,0:16:46.00,0:16:51.46,Default,,0000,0000,0000,,So if I have the SMILES, then I can check \Nthe molecular formula, for example. Dialogue: 0,0:16:51.46,0:16:53.43,Default,,0000,0000,0000,,I can check the InChIKey. Dialogue: 0,0:16:55.24,0:17:00.50,Default,,0000,0000,0000,,At some point, what we are going to do\Nis calculate physicochemical properties Dialogue: 0,0:17:00.50,0:17:03.86,Default,,0000,0000,0000,,and see if that matches \Nwhat is in Wikidata. Dialogue: 0,0:17:04.52,0:17:07.15,Default,,0000,0000,0000,,This will highlight typos Dialogue: 0,0:17:07.85,0:17:10.39,Default,,0000,0000,0000,,or wrong units, for example. Dialogue: 0,0:17:11.30,0:17:14.59,Default,,0000,0000,0000,,At this moment... \Nso this is a run of this morning. Dialogue: 0,0:17:14.59,0:17:17.99,Default,,0000,0000,0000,,What we see here \Nis two tests actually failing, Dialogue: 0,0:17:17.99,0:17:19.54,Default,,0000,0000,0000,,and this is an example of it. Dialogue: 0,0:17:19.54,0:17:23.30,Default,,0000,0000,0000,,This is the InChIKey\Nthat is computed from the isomeric SMILES Dialogue: 0,0:17:23.30,0:17:26.96,Default,,0000,0000,0000,,is different from the InChIKey\Ngiven in the entry. Dialogue: 0,0:17:27.70,0:17:32.20,Default,,0000,0000,0000,,This can result from data \Nbeing pulled in from different resources. Dialogue: 0,0:17:33.01,0:17:35.89,Default,,0000,0000,0000,,So these are entries, about 300 of them, Dialogue: 0,0:17:35.89,0:17:39.48,Default,,0000,0000,0000,,in the 160,000 chemicals \Nthat we have in Wikidata. Dialogue: 0,0:17:39.48,0:17:41.63,Default,,0000,0000,0000,,So it's a very small amount, really, Dialogue: 0,0:17:42.39,0:17:45.67,Default,,0000,0000,0000,,where there is information, \Nand someone needs to look at it. Dialogue: 0,0:17:47.32,0:17:51.01,Default,,0000,0000,0000,,Now, these are all organic compounds Dialogue: 0,0:17:51.01,0:17:54.17,Default,,0000,0000,0000,,and also quite a few inorganic compounds Dialogue: 0,0:17:54.17,0:17:57.28,Default,,0000,0000,0000,,where these things just work less well. Dialogue: 0,0:17:57.62,0:18:01.10,Default,,0000,0000,0000,,But I found in the other test \Nthat is failing Dialogue: 0,0:18:01.10,0:18:04.10,Default,,0000,0000,0000,,immediately a couple of things \Nthat are very clearly wrong. Dialogue: 0,0:18:09.19,0:18:11.76,Default,,0000,0000,0000,,PubChem is a huge database. Dialogue: 0,0:18:11.100,0:18:13.85,Default,,0000,0000,0000,,They do validation as well. Dialogue: 0,0:18:13.85,0:18:16.62,Default,,0000,0000,0000,,We are in the process \Nof submitting Wikidata there, Dialogue: 0,0:18:16.62,0:18:18.81,Default,,0000,0000,0000,,which I'm really happy about. Dialogue: 0,0:18:19.35,0:18:22.53,Default,,0000,0000,0000,,It's in the last validation step \Nat this moment. Dialogue: 0,0:18:23.32,0:18:25.64,Default,,0000,0000,0000,,And this will also mean that PubChem, Dialogue: 0,0:18:25.64,0:18:29.14,Default,,0000,0000,0000,,which has something \Nlike 100 million compounds Dialogue: 0,0:18:29.14,0:18:31.15,Default,,0000,0000,0000,,will actually link back to Wikidata. Dialogue: 0,0:18:31.49,0:18:35.12,Default,,0000,0000,0000,,It already does this, but via Wikipedia. Dialogue: 0,0:18:35.39,0:18:36.95,Default,,0000,0000,0000,,(laughing) Dialogue: 0,0:18:36.95,0:18:38.43,Default,,0000,0000,0000,,Do you recognize it? Dialogue: 0,0:18:38.43,0:18:43.07,Default,,0000,0000,0000,,With the aforementioned issues there \Nof concept mismatches. Dialogue: 0,0:18:43.59,0:18:45.69,Default,,0000,0000,0000,,So this will give us a second thing. Dialogue: 0,0:18:45.69,0:18:49.68,Default,,0000,0000,0000,,And there, also, \Nusing the same Bioclipse scripts Dialogue: 0,0:18:49.68,0:18:51.68,Default,,0000,0000,0000,,or similar Bioclipse scripts, Dialogue: 0,0:18:51.68,0:18:53.49,Default,,0000,0000,0000,,we get validation reports, Dialogue: 0,0:18:53.49,0:18:57.11,Default,,0000,0000,0000,,again indicating things \Nthat chemists should look at. Dialogue: 0,0:18:59.81,0:19:01.54,Default,,0000,0000,0000,,That basically wraps it up. Dialogue: 0,0:19:01.80,0:19:04.96,Default,,0000,0000,0000,,This is still a work in progress,\Nthe article is in preparation. Dialogue: 0,0:19:04.96,0:19:08.05,Default,,0000,0000,0000,,I've been working \Nwith Finn here in Scholia Dialogue: 0,0:19:08.05,0:19:10.70,Default,,0000,0000,0000,,to support this validation. Dialogue: 0,0:19:11.06,0:19:15.54,Default,,0000,0000,0000,,We're writing up the full work, \Nbut for now you can look up this poster. Dialogue: 0,0:19:15.54,0:19:19.35,Default,,0000,0000,0000,,The slides are on the program\Nof this session, Dialogue: 0,0:19:19.35,0:19:21.82,Default,,0000,0000,0000,,so you can look at the slides\Nand look at the details. Dialogue: 0,0:19:22.56,0:19:24.94,Default,,0000,0000,0000,,And a quick acknowledgment: Dialogue: 0,0:19:24.94,0:19:28.37,Default,,0000,0000,0000,,some of this work has been done \Nby a number of grants that I received. Dialogue: 0,0:19:28.37,0:19:29.84,Default,,0000,0000,0000,,And thank you very much. Dialogue: 0,0:19:30.28,0:19:32.48,Default,,0000,0000,0000,,(applause) Dialogue: 0,0:19:35.92,0:19:37.90,Default,,0000,0000,0000,,(chairman) Are there any questions? Dialogue: 0,0:19:41.14,0:19:42.67,Default,,0000,0000,0000,,(person 3) Thank you so much for this. Dialogue: 0,0:19:42.67,0:19:44.20,Default,,0000,0000,0000,,I am [inaudible], Dialogue: 0,0:19:44.20,0:19:47.14,Default,,0000,0000,0000,,and so far, I've been reading articles Dialogue: 0,0:19:47.14,0:19:49.72,Default,,0000,0000,0000,,on the [inaudible] Quickipedia \Non different compounds. Dialogue: 0,0:19:49.72,0:19:53.77,Default,,0000,0000,0000,,I have a little bit more than 70 articles \Nwith different compounds-- Dialogue: 0,0:19:53.77,0:19:55.46,Default,,0000,0000,0000,,just things I come across. Dialogue: 0,0:19:56.00,0:19:58.02,Default,,0000,0000,0000,,And my question to you is Dialogue: 0,0:19:58.02,0:20:02.37,Default,,0000,0000,0000,,if I want to move my chemistry activity \Nfrom Wikipedia to Wikidata, Dialogue: 0,0:20:02.37,0:20:05.30,Default,,0000,0000,0000,,how can I help\Nin a way that is very friendly Dialogue: 0,0:20:05.30,0:20:10.03,Default,,0000,0000,0000,,to somebody who is a beginner \Nin that field on Wikidata? Dialogue: 0,0:20:12.26,0:20:15.83,Default,,0000,0000,0000,,So, if that compound is in Wikipedia and.. Dialogue: 0,0:20:15.83,0:20:18.09,Default,,0000,0000,0000,,Sometimes there is \Nactually a Wikidata page. Dialogue: 0,0:20:18.09,0:20:19.97,Default,,0000,0000,0000,,I occasionally run into this as well, Dialogue: 0,0:20:19.97,0:20:21.90,Default,,0000,0000,0000,,in the last couple of months \Nnot so much anymore Dialogue: 0,0:20:21.90,0:20:23.79,Default,,0000,0000,0000,,but this morning, actually. Dialogue: 0,0:20:25.52,0:20:27.43,Default,,0000,0000,0000,,And what I typically do then Dialogue: 0,0:20:27.43,0:20:31.10,Default,,0000,0000,0000,,is I take the SMILES\Nfrom [inaudible] infobox Dialogue: 0,0:20:31.10,0:20:32.26,Default,,0000,0000,0000,,from that compound Dialogue: 0,0:20:32.26,0:20:37.18,Default,,0000,0000,0000,,or use PubChem to look up the SMILES,\Ncheck if the information is complete, Dialogue: 0,0:20:37.18,0:20:38.82,Default,,0000,0000,0000,,particularly the stereochemistry, Dialogue: 0,0:20:39.28,0:20:43.42,Default,,0000,0000,0000,,and then I use that \Nthat creates Wikidata item scripts Dialogue: 0,0:20:43.42,0:20:46.32,Default,,0000,0000,0000,,to create Quickstatements \Nfor that compound. Dialogue: 0,0:20:47.51,0:20:50.02,Default,,0000,0000,0000,,If there already is a Wikidata item, Dialogue: 0,0:20:50.02,0:20:55.92,Default,,0000,0000,0000,,I basically just update these scripts, Dialogue: 0,0:20:55.92,0:21:00.06,Default,,0000,0000,0000,,but rather than say, "Create Last,"\NI replace the last with the Q-codes Dialogue: 0,0:21:00.06,0:21:01.71,Default,,0000,0000,0000,,that that item already has. Dialogue: 0,0:21:01.71,0:21:04.65,Default,,0000,0000,0000,,And then it complements \Nor it adds this information Dialogue: 0,0:21:04.65,0:21:06.99,Default,,0000,0000,0000,,based on the information we had. Dialogue: 0,0:21:07.92,0:21:10.42,Default,,0000,0000,0000,,This is [manuable], Dialogue: 0,0:21:10.42,0:21:13.68,Default,,0000,0000,0000,,so you can copy-paste \Na number of SMILES, put it in a file, Dialogue: 0,0:21:13.68,0:21:15.100,Default,,0000,0000,0000,,and take that. Dialogue: 0,0:21:18.35,0:21:21.67,Default,,0000,0000,0000,,Extracting that information to Wikidata \Nis not something I've automated yet, Dialogue: 0,0:21:21.67,0:21:25.09,Default,,0000,0000,0000,,but this helps me... \Nit's a pretty fast process. Dialogue: 0,0:21:25.78,0:21:28.43,Default,,0000,0000,0000,,I can show you later \Nhow to use that software. Dialogue: 0,0:21:30.73,0:21:32.48,Default,,0000,0000,0000,,(chairman) Are there other questions? Dialogue: 0,0:21:33.52,0:21:34.78,Default,,0000,0000,0000,,So, I have one. Dialogue: 0,0:21:35.10,0:21:39.82,Default,,0000,0000,0000,,Do you make an effort \Nto, in fact, make this more visible Dialogue: 0,0:21:39.82,0:21:42.44,Default,,0000,0000,0000,,in this bioinformatics community Dialogue: 0,0:21:42.44,0:21:46.67,Default,,0000,0000,0000,,so that they can start using\Nthis structured data? Dialogue: 0,0:21:47.57,0:21:49.33,Default,,0000,0000,0000,,Yeah, I'm actively doing that. Dialogue: 0,0:21:49.33,0:21:52.26,Default,,0000,0000,0000,,So what I did not mention \Nin this presentation so much, Dialogue: 0,0:21:52.26,0:21:58.46,Default,,0000,0000,0000,,but we saw that in...\NI'd have somewhere to start here-- Dialogue: 0,0:21:58.46,0:22:00.67,Default,,0000,0000,0000,,this is an overview \Nof different databases. Dialogue: 0,0:22:01.11,0:22:04.71,Default,,0000,0000,0000,,A similar plot, which actually \NI do not have on this slide deck Dialogue: 0,0:22:04.71,0:22:09.39,Default,,0000,0000,0000,,is the number of different identifiers\Nthat chemical compounds have, Dialogue: 0,0:22:09.39,0:22:11.35,Default,,0000,0000,0000,,and I've been working \Nwith a number of databases, Dialogue: 0,0:22:11.35,0:22:15.62,Default,,0000,0000,0000,,like MassBank, \Nthe Environmental Protection Agency, Dialogue: 0,0:22:17.18,0:22:18.99,Default,,0000,0000,0000,,CompTox Dashboard. Dialogue: 0,0:22:19.51,0:22:21.70,Default,,0000,0000,0000,,I've added links to the BDB database. Dialogue: 0,0:22:21.70,0:22:24.16,Default,,0000,0000,0000,,So I'm working with a number of projects Dialogue: 0,0:22:24.16,0:22:27.47,Default,,0000,0000,0000,,for pulling in additional information, Dialogue: 0,0:22:27.74,0:22:30.03,Default,,0000,0000,0000,,identifies our links out\Nto other databases. Dialogue: 0,0:22:31.19,0:22:33.37,Default,,0000,0000,0000,,Regarding outreach, yes, Dialogue: 0,0:22:33.37,0:22:36.96,Default,,0000,0000,0000,,so that wrong slide deck\Nthat I was showing at the start, Dialogue: 0,0:22:36.96,0:22:39.28,Default,,0000,0000,0000,,there was actually \Na presentation two weeks ago Dialogue: 0,0:22:39.28,0:22:42.15,Default,,0000,0000,0000,,at an Open Science Meeting \Naround chemistry. Dialogue: 0,0:22:42.50,0:22:45.84,Default,,0000,0000,0000,,I'm very much pushing this and... Dialogue: 0,0:22:47.41,0:22:48.95,Default,,0000,0000,0000,,I see a big future here. Dialogue: 0,0:22:48.95,0:22:50.78,Default,,0000,0000,0000,,There's a lot of interest. Dialogue: 0,0:22:50.78,0:22:54.59,Default,,0000,0000,0000,,And making people aware \Nof the CC0 license, Dialogue: 0,0:22:54.59,0:22:57.62,Default,,0000,0000,0000,,that's typically the larger problem. Dialogue: 0,0:22:58.20,0:23:02.97,Default,,0000,0000,0000,,So we have to pull in\Nthe information carefully. Dialogue: 0,0:23:05.30,0:23:06.71,Default,,0000,0000,0000,,(chairman) Other questions? Dialogue: 0,0:23:08.64,0:23:10.37,Default,,0000,0000,0000,,- Okay. \N- Thank you very much. Dialogue: 0,0:23:10.37,0:23:12.04,Default,,0000,0000,0000,,(chairman) Can we thank the speaker. Dialogue: 0,0:23:12.04,0:23:15.26,Default,,0000,0000,0000,,(applause)