[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:00.74,0:00:02.38,Default,,0000,0000,0000,,Spavanje.
Dialogue: 0,0:00:02.38,0:00:05.20,Default,,0000,0000,0000,,U tome provodimo trećinu svog života,
Dialogue: 0,0:00:05.20,0:00:08.52,Default,,0000,0000,0000,,ali da li iko od nas zna o čemu se tu\Nzapravo radi?
Dialogue: 0,0:00:08.52,0:00:10.74,Default,,0000,0000,0000,,Prije 2000 godina, Galen,
Dialogue: 0,0:00:10.74,0:00:12.88,Default,,0000,0000,0000,,jedan od najistaknutijih istraživača\Nmedicine
Dialogue: 0,0:00:12.88,0:00:13.94,Default,,0000,0000,0000,,antičkog doba
Dialogue: 0,0:00:13.94,0:00:16.26,Default,,0000,0000,0000,,predložio je da motivaciona snaga\Nnašeg mozga,
Dialogue: 0,0:00:16.26,0:00:19.62,Default,,0000,0000,0000,,njegovi sokovi, u budnom stanju
Dialogue: 0,0:00:19.62,0:00:22.19,Default,,0000,0000,0000,,protiču kroz sve druge dijelove tijela
Dialogue: 0,0:00:22.19,0:00:26.20,Default,,0000,0000,0000,,i animiraju ih, ali time iscrpljuju mozak.
Dialogue: 0,0:00:26.20,0:00:27.82,Default,,0000,0000,0000,,Galen je pomislio da dok spavamo
Dialogue: 0,0:00:27.82,0:00:30.36,Default,,0000,0000,0000,,sva ta vlažnost koja je ispunila ostatak\Ntijela
Dialogue: 0,0:00:30.36,0:00:32.10,Default,,0000,0000,0000,,naglo bi se vratila
Dialogue: 0,0:00:32.10,0:00:33.91,Default,,0000,0000,0000,,i hidrirala mozak
Dialogue: 0,0:00:33.91,0:00:36.46,Default,,0000,0000,0000,,i osvježila um.
Dialogue: 0,0:00:36.46,0:00:38.88,Default,,0000,0000,0000,,Nama to sada zvuči baš smiješno,
Dialogue: 0,0:00:38.88,0:00:40.92,Default,,0000,0000,0000,,ali Galen je prosto pokušao da\Nobjasni
Dialogue: 0,0:00:40.92,0:00:42.53,Default,,0000,0000,0000,,nešto vezano za san
Dialogue: 0,0:00:42.53,0:00:45.18,Default,,0000,0000,0000,,sa čime se susrećemo svaki dan.
Dialogue: 0,0:00:45.18,0:00:47.11,Default,,0000,0000,0000,,Na osnovu svog iskustva, svi znamo
Dialogue: 0,0:00:47.11,0:00:49.82,Default,,0000,0000,0000,,da nam san razbistruje um
Dialogue: 0,0:00:49.82,0:00:51.28,Default,,0000,0000,0000,,i nedostatak istog
Dialogue: 0,0:00:51.28,0:00:54.21,Default,,0000,0000,0000,,čini naš um mutnim.
Dialogue: 0,0:00:54.21,0:00:56.72,Default,,0000,0000,0000,,Iako se danas zna mnogo više o snu
Dialogue: 0,0:00:56.72,0:00:58.53,Default,,0000,0000,0000,,nego kad je Galen bio živ,
Dialogue: 0,0:00:58.53,0:01:01.41,Default,,0000,0000,0000,,još uvijek ne znamo zašto san
Dialogue: 0,0:01:01.41,0:01:04.04,Default,,0000,0000,0000,,pored svih drugih aktivnosti, ima\Nnevjerovatnu
Dialogue: 0,0:01:04.04,0:01:06.75,Default,,0000,0000,0000,,iscjeliteljsku moć nad našim umom.
Dialogue: 0,0:01:06.75,0:01:08.25,Default,,0000,0000,0000,,Danas želim da vam pričam
Dialogue: 0,0:01:08.25,0:01:09.61,Default,,0000,0000,0000,,o nedavnom istraživanju
Dialogue: 0,0:01:09.61,0:01:12.37,Default,,0000,0000,0000,,koje možda rasvijetli ovo pitanje.
Dialogue: 0,0:01:12.37,0:01:15.57,Default,,0000,0000,0000,,Otkrili smo da je san zapravo
Dialogue: 0,0:01:15.57,0:01:17.95,Default,,0000,0000,0000,,takoreći elegantno rješenje
Dialogue: 0,0:01:17.95,0:01:21.01,Default,,0000,0000,0000,,za neke od najosnovnijih potreba mozga,
Dialogue: 0,0:01:21.01,0:01:22.47,Default,,0000,0000,0000,,jedinstven način na koji mozak
Dialogue: 0,0:01:22.47,0:01:25.29,Default,,0000,0000,0000,,odgovara na velike zahtijeve i finese
Dialogue: 0,0:01:25.29,0:01:30.29,Default,,0000,0000,0000,,koje ga razdvajaju od ostalih organa\Ntijela.
Dialogue: 0,0:01:30.29,0:01:33.35,Default,,0000,0000,0000,,Skoro sva biologija koju posmatramo
Dialogue: 0,0:01:33.35,0:01:35.80,Default,,0000,0000,0000,,može se okarakterisati kao niz\Nproblema
Dialogue: 0,0:01:35.80,0:01:37.84,Default,,0000,0000,0000,,i odgovarajućih rješenja.
Dialogue: 0,0:01:37.84,0:01:41.32,Default,,0000,0000,0000,,Prvi problem koji svaki organ mora da\Nriješi
Dialogue: 0,0:01:41.32,0:01:43.82,Default,,0000,0000,0000,,je konstantna opskrba svih tih ćelija
Dialogue: 0,0:01:43.82,0:01:45.56,Default,,0000,0000,0000,,hranjivim materijama.
Dialogue: 0,0:01:45.56,0:01:48.14,Default,,0000,0000,0000,,To je posebno bitno za mozak.
Dialogue: 0,0:01:48.14,0:01:50.36,Default,,0000,0000,0000,,Njegova intenzivna električna aktivnost\Ncrpi
Dialogue: 0,0:01:50.36,0:01:53.21,Default,,0000,0000,0000,,četvrtinu ukupne energije tijela
Dialogue: 0,0:01:53.21,0:01:54.84,Default,,0000,0000,0000,,iako mozak zauzima
Dialogue: 0,0:01:54.84,0:01:58.18,Default,,0000,0000,0000,,samo oko 2 procenta tjelesne mase.
Dialogue: 0,0:01:58.18,0:01:59.79,Default,,0000,0000,0000,,Krvotok rješava
Dialogue: 0,0:01:59.79,0:02:02.22,Default,,0000,0000,0000,,problem dostave hranjivih materija
Dialogue: 0,0:02:02.22,0:02:04.76,Default,,0000,0000,0000,,šaljući krvne sudove da obskrbe tim\Nmaterijama
Dialogue: 0,0:02:04.76,0:02:08.11,Default,,0000,0000,0000,,i kiseonikom svaki pedalj našeg tijela.
Dialogue: 0,0:02:08.11,0:02:11.12,Default,,0000,0000,0000,,To možete vidjeti na ovom snimku.
Dialogue: 0,0:02:11.12,0:02:12.70,Default,,0000,0000,0000,,Ovdje su prikazani krvni sudovi
Dialogue: 0,0:02:12.70,0:02:15.60,Default,,0000,0000,0000,,u mozgu živog miša.
Dialogue: 0,0:02:15.60,0:02:18.12,Default,,0000,0000,0000,,Krvni sudovi formiraju složenu mrežu
Dialogue: 0,0:02:18.12,0:02:20.46,Default,,0000,0000,0000,,koja ispunjava čitavu zapreminu mozga.
Dialogue: 0,0:02:20.46,0:02:22.27,Default,,0000,0000,0000,,Oni počinju na površini mozga
Dialogue: 0,0:02:22.27,0:02:25.15,Default,,0000,0000,0000,,a onda zadiru u samo tkivo.
Dialogue: 0,0:02:25.15,0:02:27.51,Default,,0000,0000,0000,,Dok se šire, opskrbljuju svaku moždanu\Nćeliju\N
Dialogue: 0,0:02:27.51,0:02:33.27,Default,,0000,0000,0000,,hranjivim materijama i kiseonikom .
Dialogue: 0,0:02:33.28,0:02:36.25,Default,,0000,0000,0000,,Kao što svakoj ćeliji trebaju
Dialogue: 0,0:02:36.25,0:02:38.14,Default,,0000,0000,0000,,ove materije za pogon,
Dialogue: 0,0:02:38.14,0:02:41.28,Default,,0000,0000,0000,,svaka ćelija proizvodi otpad
Dialogue: 0,0:02:41.28,0:02:42.82,Default,,0000,0000,0000,,i uklanjanje tog otpada
Dialogue: 0,0:02:42.82,0:02:45.09,Default,,0000,0000,0000,,je drugi osnovni problem koji
Dialogue: 0,0:02:45.09,0:02:47.88,Default,,0000,0000,0000,,svaki organ treba da riješi.
Dialogue: 0,0:02:47.88,0:02:50.46,Default,,0000,0000,0000,,Ovaj dijagram prikazuje tjelesni limfni\Nsistem
Dialogue: 0,0:02:50.46,0:02:52.90,Default,,0000,0000,0000,,koji je evoluirao kako bi riješio\Novaj problem.
Dialogue: 0,0:02:52.90,0:02:55.71,Default,,0000,0000,0000,,Ovo je drugi paralelni sistem sudova
Dialogue: 0,0:02:55.71,0:02:57.72,Default,,0000,0000,0000,,koji se prostire po cijelom tijelu.
Dialogue: 0,0:02:57.72,0:02:59.68,Default,,0000,0000,0000,,On sakuplja proteine i drugi otpad
Dialogue: 0,0:02:59.68,0:03:01.60,Default,,0000,0000,0000,,iz međućelijskih dijelova
Dialogue: 0,0:03:01.60,0:03:04.41,Default,,0000,0000,0000,,i onda ih premiješta u krv
Dialogue: 0,0:03:04.41,0:03:06.68,Default,,0000,0000,0000,,kako bi se oni otklonili.
Dialogue: 0,0:03:06.68,0:03:08.46,Default,,0000,0000,0000,,Ako pažljivije pogledate ovaj\Ndijagram
Dialogue: 0,0:03:08.46,0:03:09.86,Default,,0000,0000,0000,,primijetićete da nešto
Dialogue: 0,0:03:09.86,0:03:12.19,Default,,0000,0000,0000,,ne štima.
Dialogue: 0,0:03:12.19,0:03:14.94,Default,,0000,0000,0000,,Ako biste zumirali glavu ovog čovjeka
Dialogue: 0,0:03:14.94,0:03:17.14,Default,,0000,0000,0000,,ono što vidite je da
Dialogue: 0,0:03:17.14,0:03:21.30,Default,,0000,0000,0000,,u mozgu nema limfnih sudova.
Dialogue: 0,0:03:21.30,0:03:24.39,Default,,0000,0000,0000,,Ali to nema mnogo smisla.
Dialogue: 0,0:03:24.39,0:03:27.60,Default,,0000,0000,0000,,Mozak je jedan izuzetno intenzivan\Norgan
Dialogue: 0,0:03:27.60,0:03:30.16,Default,,0000,0000,0000,,koji shodno tome proizvodi velike\Nkoličine otpada
Dialogue: 0,0:03:30.16,0:03:32.74,Default,,0000,0000,0000,,koji se mora učinkovito otkloniti.
Dialogue: 0,0:03:32.74,0:03:35.70,Default,,0000,0000,0000,,Ipak, on nema limfne sudove,\Nšto znači da
Dialogue: 0,0:03:35.70,0:03:37.50,Default,,0000,0000,0000,,pristup koji ostatak tijela koristi
Dialogue: 0,0:03:37.50,0:03:39.48,Default,,0000,0000,0000,,kako bi otklonio otpad
Dialogue: 0,0:03:39.48,0:03:42.49,Default,,0000,0000,0000,,neće djelovati u mozgu.
Dialogue: 0,0:03:42.49,0:03:44.54,Default,,0000,0000,0000,,Kako onda mozak rješava
Dialogue: 0,0:03:44.54,0:03:46.29,Default,,0000,0000,0000,,problem odstranjivanja otpada?
Dialogue: 0,0:03:46.29,0:03:49.98,Default,,0000,0000,0000,,Kod ovog naizgled svakodnevnog pitanja
Dialogue: 0,0:03:49.98,0:03:53.39,Default,,0000,0000,0000,,naša prva grupa ulazi u igru.
Dialogue: 0,0:03:53.39,0:03:55.41,Default,,0000,0000,0000,,Ono što smo otkrili
Dialogue: 0,0:03:55.41,0:03:57.75,Default,,0000,0000,0000,,zaronivši dublje u mozak
Dialogue: 0,0:03:57.75,0:04:00.64,Default,,0000,0000,0000,,dole među neurone i krvne sudove
Dialogue: 0,0:04:00.64,0:04:02.82,Default,,0000,0000,0000,,bilo je da je rješenje mozga
Dialogue: 0,0:04:02.82,0:04:05.38,Default,,0000,0000,0000,,za odstranjivanje otpada
Dialogue: 0,0:04:05.38,0:04:07.20,Default,,0000,0000,0000,,sasvim nesvakidašnje.
Dialogue: 0,0:04:07.20,0:04:10.05,Default,,0000,0000,0000,,Bilo je genijalno,
Dialogue: 0,0:04:10.05,0:04:13.17,Default,,0000,0000,0000,,ali i prelijepo.
Dialogue: 0,0:04:13.17,0:04:14.84,Default,,0000,0000,0000,,Da vam ispričam šta smo našli.
Dialogue: 0,0:04:14.84,0:04:17.39,Default,,0000,0000,0000,,Mozak ima prostor prepun
Dialogue: 0,0:04:17.39,0:04:20.85,Default,,0000,0000,0000,,čiste i bistre tečnosti koja se zove\Ncerebrospinalna tečnost.
Dialogue: 0,0:04:20.85,0:04:22.17,Default,,0000,0000,0000,,Mi je zovemo CST.
Dialogue: 0,0:04:22.17,0:04:26.15,Default,,0000,0000,0000,,CST ispunjava prostor koji okružuje\Nmozak
Dialogue: 0,0:04:26.15,0:04:27.67,Default,,0000,0000,0000,,i otpad iz mozga
Dialogue: 0,0:04:27.67,0:04:29.89,Default,,0000,0000,0000,,ulazi u CST
Dialogue: 0,0:04:29.89,0:04:33.16,Default,,0000,0000,0000,,koja se zajedno s otpadnom uliva u krv.
Dialogue: 0,0:04:33.16,0:04:34.28,Default,,0000,0000,0000,,Ovo puno zvuči kao
Dialogue: 0,0:04:34.28,0:04:36.87,Default,,0000,0000,0000,,limfni sistem, zar ne?
Dialogue: 0,0:04:36.87,0:04:39.62,Default,,0000,0000,0000,,Ono što je interesantno je da tečnost\Ni otpad
Dialogue: 0,0:04:39.62,0:04:41.36,Default,,0000,0000,0000,,iz mozga
Dialogue: 0,0:04:41.36,0:04:43.76,Default,,0000,0000,0000,,ne izlaze nasumično
Dialogue: 0,0:04:43.76,0:04:46.14,Default,,0000,0000,0000,,iz ovog prostora CST-a.
Dialogue: 0,0:04:46.14,0:04:49.86,Default,,0000,0000,0000,,Naprotiv, postoji specijalizovan sistem
Dialogue: 0,0:04:49.86,0:04:53.75,Default,,0000,0000,0000,,koji organizuje i podupire ovaj proces.
Dialogue: 0,0:04:53.75,0:04:55.90,Default,,0000,0000,0000,,To možete vidjeti na ovim snimcima.
Dialogue: 0,0:04:55.90,0:04:58.94,Default,,0000,0000,0000,,Ovdje ponovo imate prikaz mozga
Dialogue: 0,0:04:58.94,0:05:00.42,Default,,0000,0000,0000,,živog miša.
Dialogue: 0,0:05:00.42,0:05:02.35,Default,,0000,0000,0000,,Slika lijevo prikazuje
Dialogue: 0,0:05:02.35,0:05:04.41,Default,,0000,0000,0000,,šta se dešava na površini mozga
Dialogue: 0,0:05:04.41,0:05:05.97,Default,,0000,0000,0000,,a slika desno prikazuje
Dialogue: 0,0:05:05.97,0:05:07.92,Default,,0000,0000,0000,,šta se dešava ispod površine mozga
Dialogue: 0,0:05:07.92,0:05:09.64,Default,,0000,0000,0000,,unutar samog tkiva.
Dialogue: 0,0:05:09.64,0:05:11.90,Default,,0000,0000,0000,,Krvni sudovi su crvene boje
Dialogue: 0,0:05:11.90,0:05:13.92,Default,,0000,0000,0000,,a CST koja okružuje mozak
Dialogue: 0,0:05:13.92,0:05:15.74,Default,,0000,0000,0000,,je zelene.
Dialogue: 0,0:05:15.74,0:05:17.54,Default,,0000,0000,0000,,Ono što nas je iznenadilo je
Dialogue: 0,0:05:17.54,0:05:20.80,Default,,0000,0000,0000,,to da tečnost izvan mozga
Dialogue: 0,0:05:20.80,0:05:23.61,Default,,0000,0000,0000,,nije ostala izvan njega.
Dialogue: 0,0:05:23.61,0:05:27.01,Default,,0000,0000,0000,,CST se vratila unutar
Dialogue: 0,0:05:27.01,0:05:28.88,Default,,0000,0000,0000,,i prošla kroz krv
Dialogue: 0,0:05:28.88,0:05:31.92,Default,,0000,0000,0000,,duž vanjskog dijela krvnih sudova.
Dialogue: 0,0:05:31.92,0:05:34.30,Default,,0000,0000,0000,,Dok se spuštala u mozak
Dialogue: 0,0:05:34.30,0:05:36.10,Default,,0000,0000,0000,,duž vanjskog dijela ovih sudova
Dialogue: 0,0:05:36.10,0:05:38.91,Default,,0000,0000,0000,,ona je zapravo pomagala u otklanjanju
Dialogue: 0,0:05:38.91,0:05:41.35,Default,,0000,0000,0000,,otpada iz
Dialogue: 0,0:05:41.35,0:05:44.20,Default,,0000,0000,0000,,međućelijskog prostora.
Dialogue: 0,0:05:44.20,0:05:46.11,Default,,0000,0000,0000,,Ako razmislite o tome,
Dialogue: 0,0:05:46.11,0:05:49.59,Default,,0000,0000,0000,,korištenje vanjskog dijela ovih sudova
Dialogue: 0,0:05:49.59,0:05:52.11,Default,,0000,0000,0000,,je jako pametno rješenje
Dialogue: 0,0:05:52.11,0:05:54.83,Default,,0000,0000,0000,,jer je mozak zatvoren
Dialogue: 0,0:05:54.83,0:05:56.65,Default,,0000,0000,0000,,u čvrstu lobanju
Dialogue: 0,0:05:56.65,0:05:58.76,Default,,0000,0000,0000,,i prepun je ćelija
Dialogue: 0,0:05:58.76,0:06:01.50,Default,,0000,0000,0000,,tako da u njemu nema dodatnog\Nprostora
Dialogue: 0,0:06:01.50,0:06:05.10,Default,,0000,0000,0000,,za čitav set sudova jednog\Nlimfnog sistema.
Dialogue: 0,0:06:05.10,0:06:06.36,Default,,0000,0000,0000,,Ipak, krvni sudovi
Dialogue: 0,0:06:06.36,0:06:08.32,Default,,0000,0000,0000,,se protežu sa površine mozga
Dialogue: 0,0:06:08.32,0:06:10.93,Default,,0000,0000,0000,,do svake žive ćelije mozga
Dialogue: 0,0:06:10.93,0:06:12.16,Default,,0000,0000,0000,,što znači da tečnost
Dialogue: 0,0:06:12.16,0:06:15.46,Default,,0000,0000,0000,,koja putuje duž vanjskog dijela krvnih\Nsudova
Dialogue: 0,0:06:15.46,0:06:19.26,Default,,0000,0000,0000,,može dobiti pristup cijelokupnoj\Nzapremini mozga,
Dialogue: 0,0:06:19.26,0:06:21.22,Default,,0000,0000,0000,,tako da je ovo jako pametan način
Dialogue: 0,0:06:21.22,0:06:25.21,Default,,0000,0000,0000,,za prekvalifikaciju jednog seta sudova,\N
Dialogue: 0,0:06:25.21,0:06:27.100,Default,,0000,0000,0000,,krvnih sudova, koji preuzimaju funkciju
Dialogue: 0,0:06:27.100,0:06:31.18,Default,,0000,0000,0000,,drugog seta sudova, limfnih sudova
Dialogue: 0,0:06:31.18,0:06:33.59,Default,,0000,0000,0000,,kako bi se pobrinuli da ih ne trebamo.
Dialogue: 0,0:06:33.59,0:06:35.91,Default,,0000,0000,0000,,Ono što je zapanjujuće je da nijedan\Ndrugi organ
Dialogue: 0,0:06:35.91,0:06:37.55,Default,,0000,0000,0000,,ne koristi ovaj pristup
Dialogue: 0,0:06:37.55,0:06:40.61,Default,,0000,0000,0000,,kako bi otklonio međućelijski otpad.
Dialogue: 0,0:06:40.61,0:06:46.43,Default,,0000,0000,0000,,Ovo rješenje je karakteristično samo\Nza mozak.
Dialogue: 0,0:06:46.43,0:06:48.70,Default,,0000,0000,0000,,Ali najiznenađujuće otkriće
Dialogue: 0,0:06:48.70,0:06:50.80,Default,,0000,0000,0000,,je da se sve ovo
Dialogue: 0,0:06:50.80,0:06:53.15,Default,,0000,0000,0000,,što sam vam rekao
Dialogue: 0,0:06:53.15,0:06:56.47,Default,,0000,0000,0000,,o ovoj tečnosti koja ide kroz mozak
Dialogue: 0,0:06:56.47,0:07:00.65,Default,,0000,0000,0000,,samo se dešava u stanju sna.
Dialogue: 0,0:07:00.65,0:07:02.10,Default,,0000,0000,0000,,Snimak lijevo
Dialogue: 0,0:07:02.10,0:07:04.36,Default,,0000,0000,0000,,pokazuje koliko se CST kreće
Dialogue: 0,0:07:04.36,0:07:07.97,Default,,0000,0000,0000,,kroz mozak miša koji je budan.
Dialogue: 0,0:07:07.97,0:07:09.84,Default,,0000,0000,0000,,Skoro pa ništa.
Dialogue: 0,0:07:09.84,0:07:11.42,Default,,0000,0000,0000,,Ali u istoj životinji
Dialogue: 0,0:07:11.42,0:07:14.62,Default,,0000,0000,0000,,ako samo malo sačekamo da zaspi
Dialogue: 0,0:07:14.62,0:07:17.38,Default,,0000,0000,0000,,ono što vidimo je da CST
Dialogue: 0,0:07:17.38,0:07:19.80,Default,,0000,0000,0000,,poput bujice ide kroz mozak.
Dialogue: 0,0:07:19.80,0:07:21.96,Default,,0000,0000,0000,,Otkrili smo i da u isto vrijeme
Dialogue: 0,0:07:21.96,0:07:24.57,Default,,0000,0000,0000,,kada mozak zaspi
Dialogue: 0,0:07:24.57,0:07:27.23,Default,,0000,0000,0000,,moždane ćelije se, čini se, smanje
Dialogue: 0,0:07:27.23,0:07:29.27,Default,,0000,0000,0000,,i daju malo međuprostora,
Dialogue: 0,0:07:29.27,0:07:31.41,Default,,0000,0000,0000,,što omogućava tečnosti da jurne
Dialogue: 0,0:07:31.41,0:07:34.14,Default,,0000,0000,0000,,i time očisti otpad.
Dialogue: 0,0:07:34.14,0:07:36.65,Default,,0000,0000,0000,,Izgleda da je Galen zapravo
Dialogue: 0,0:07:36.65,0:07:38.91,Default,,0000,0000,0000,,bio na pravom putu kada je pisao o
Dialogue: 0,0:07:38.91,0:07:41.61,Default,,0000,0000,0000,,tečnosti koja šiklja kroz mozak
Dialogue: 0,0:07:41.61,0:07:43.25,Default,,0000,0000,0000,,kada spavamo.
Dialogue: 0,0:07:43.25,0:07:46.70,Default,,0000,0000,0000,,Naše istraživanje, 2000 godina poslije,
Dialogue: 0,0:07:46.70,0:07:48.78,Default,,0000,0000,0000,,upućuje na to da
Dialogue: 0,0:07:48.78,0:07:50.83,Default,,0000,0000,0000,,kada je mozak budan
Dialogue: 0,0:07:50.83,0:07:52.95,Default,,0000,0000,0000,,i najzauzetiji
Dialogue: 0,0:07:52.95,0:07:55.31,Default,,0000,0000,0000,,on odgađa odstranjivanje otpada
Dialogue: 0,0:07:55.31,0:07:58.38,Default,,0000,0000,0000,,iz međućelijskog prostora
Dialogue: 0,0:07:58.38,0:08:00.24,Default,,0000,0000,0000,,i onda kada zaspi
Dialogue: 0,0:08:00.24,0:08:02.59,Default,,0000,0000,0000,,i nije toliko zauzet
Dialogue: 0,0:08:02.59,0:08:05.16,Default,,0000,0000,0000,,prebacuje se u stanje čišćenja
Dialogue: 0,0:08:05.16,0:08:06.85,Default,,0000,0000,0000,,i odstranjuje otpad
Dialogue: 0,0:08:06.85,0:08:08.36,Default,,0000,0000,0000,,iz međućelijskog prostora,
Dialogue: 0,0:08:08.36,0:08:10.78,Default,,0000,0000,0000,,otpad koji se nakuplja tokom dana.
Dialogue: 0,0:08:10.78,0:08:13.18,Default,,0000,0000,0000,,To je nekako kao kad vi ili ja
Dialogue: 0,0:08:13.18,0:08:16.27,Default,,0000,0000,0000,,odgađamo naše kućanske poslove\Nu toku radne sedmice
Dialogue: 0,0:08:16.27,0:08:17.73,Default,,0000,0000,0000,,kada nemamo puno vremena
Dialogue: 0,0:08:17.73,0:08:20.99,Default,,0000,0000,0000,,i onda kada dođe vikend
Dialogue: 0,0:08:20.99,0:08:23.75,Default,,0000,0000,0000,,trudimo se da sve nadoknadimo.
Dialogue: 0,0:08:23.75,0:08:27.02,Default,,0000,0000,0000,,Puno sam pričao o odstranjivanju\Notpada
Dialogue: 0,0:08:27.02,0:08:28.47,Default,,0000,0000,0000,,ali nisam bio konkretan
Dialogue: 0,0:08:28.47,0:08:29.87,Default,,0000,0000,0000,,u vezi sa tipovima otpada
Dialogue: 0,0:08:29.87,0:08:32.16,Default,,0000,0000,0000,,koje mozak treba da odstrani
Dialogue: 0,0:08:32.16,0:08:34.70,Default,,0000,0000,0000,,tokom sna kako bi ostao zdrav.
Dialogue: 0,0:08:34.70,0:08:36.30,Default,,0000,0000,0000,,Štetni proizvod na koji se\N
Dialogue: 0,0:08:36.30,0:08:38.72,Default,,0000,0000,0000,,recentne studije mahom fokusiraju\Nje amiloid-beta.
Dialogue: 0,0:08:38.72,0:08:41.91,Default,,0000,0000,0000,,To je protein koji se konstantno proizvodi\Nu mozgu.
Dialogue: 0,0:08:41.91,0:08:43.77,Default,,0000,0000,0000,,Moj mozak upravo proizvodi\Namiloid-betu
Dialogue: 0,0:08:43.77,0:08:45.93,Default,,0000,0000,0000,,a i vaš.
Dialogue: 0,0:08:45.93,0:08:47.93,Default,,0000,0000,0000,,Ali kog oboljelih od Alchajmerove
Dialogue: 0,0:08:47.93,0:08:50.53,Default,,0000,0000,0000,,amiloid-beta se nakuplja
Dialogue: 0,0:08:50.53,0:08:52.54,Default,,0000,0000,0000,,u međućelijskom prostoru
Dialogue: 0,0:08:52.54,0:08:55.97,Default,,0000,0000,0000,,umjesto da se otklanja
Dialogue: 0,0:08:55.97,0:08:57.98,Default,,0000,0000,0000,,i smatra se da su upravo ove nakupine\N
Dialogue: 0,0:08:57.98,0:09:00.19,Default,,0000,0000,0000,,amiloid-bete jedan od ključnih koraka
Dialogue: 0,0:09:00.19,0:09:02.81,Default,,0000,0000,0000,,u razvitku ove strašne bolesti.
Dialogue: 0,0:09:02.81,0:09:05.91,Default,,0000,0000,0000,,Izmjerili smo koliko brzo se amiloid-beta\Notklanja
Dialogue: 0,0:09:05.91,0:09:07.64,Default,,0000,0000,0000,,iz mozga u budnom stanju
Dialogue: 0,0:09:07.64,0:09:09.42,Default,,0000,0000,0000,,a koliko u snu.
Dialogue: 0,0:09:09.42,0:09:11.30,Default,,0000,0000,0000,,Otkrili smo da, zaista,
Dialogue: 0,0:09:11.30,0:09:13.19,Default,,0000,0000,0000,,otklanjanje amiloid-bete
Dialogue: 0,0:09:13.19,0:09:17.70,Default,,0000,0000,0000,,je mnogo brže u mozgu koji spava.
Dialogue: 0,0:09:17.70,0:09:19.38,Default,,0000,0000,0000,,Ako je spavanje
Dialogue: 0,0:09:19.38,0:09:21.34,Default,,0000,0000,0000,,dio rješenja mozga
Dialogue: 0,0:09:21.34,0:09:23.35,Default,,0000,0000,0000,,za problem otklanjanja otpada
Dialogue: 0,0:09:23.35,0:09:25.73,Default,,0000,0000,0000,,onda će ovo itekako promijeniti\Nnaše razmišljanje
Dialogue: 0,0:09:25.73,0:09:27.96,Default,,0000,0000,0000,,o vezi između sna,
Dialogue: 0,0:09:27.96,0:09:31.32,Default,,0000,0000,0000,,amiloid-bete i Alchajmerove bolesti.
Dialogue: 0,0:09:31.32,0:09:33.28,Default,,0000,0000,0000,,Niz skorašnjih kliničkih studija
Dialogue: 0,0:09:33.28,0:09:35.11,Default,,0000,0000,0000,,upućuje da među pacijentima
Dialogue: 0,0:09:35.11,0:09:38.20,Default,,0000,0000,0000,,koji još uvijek nisu\Ndobili Alchajmerovu
Dialogue: 0,0:09:38.20,0:09:41.27,Default,,0000,0000,0000,,pogoršano spavanje i njegovo trajanje
Dialogue: 0,0:09:41.27,0:09:43.29,Default,,0000,0000,0000,,su povezani sa većom količinom
Dialogue: 0,0:09:43.29,0:09:46.10,Default,,0000,0000,0000,,nakupina amiloid-bete u mozgu.
Dialogue: 0,0:09:46.10,0:09:47.97,Default,,0000,0000,0000,,Važno je istaknuti da, iako
Dialogue: 0,0:09:47.97,0:09:49.68,Default,,0000,0000,0000,,ove studije ne dokazuju
Dialogue: 0,0:09:49.68,0:09:51.87,Default,,0000,0000,0000,,da nedostatak ili loš san
Dialogue: 0,0:09:51.87,0:09:54.27,Default,,0000,0000,0000,,uzrokuju Alchajmerovu,
Dialogue: 0,0:09:54.27,0:09:56.88,Default,,0000,0000,0000,,one upućuju da neuspjeh mozga
Dialogue: 0,0:09:56.88,0:09:58.80,Default,,0000,0000,0000,,da očisti kuću
Dialogue: 0,0:09:58.80,0:10:01.55,Default,,0000,0000,0000,,uklanjajući otpad poput\Namiloid-bete
Dialogue: 0,0:10:01.55,0:10:03.45,Default,,0000,0000,0000,,može doprinijeti razvitku
Dialogue: 0,0:10:03.45,0:10:07.07,Default,,0000,0000,0000,,bolesti poput Alchajmerove.
Dialogue: 0,0:10:07.07,0:10:08.98,Default,,0000,0000,0000,,Ono što nam ovo istraživanje\Ngovori
Dialogue: 0,0:10:08.98,0:10:11.30,Default,,0000,0000,0000,,je da jedna stvar koju ste svi
Dialogue: 0,0:10:11.30,0:10:12.71,Default,,0000,0000,0000,,već znali o snu,
Dialogue: 0,0:10:12.71,0:10:15.36,Default,,0000,0000,0000,,koju je čak i Galen shvatio,
Dialogue: 0,0:10:15.36,0:10:18.43,Default,,0000,0000,0000,,da osvježava i razbistruje um,
Dialogue: 0,0:10:18.43,0:10:19.98,Default,,0000,0000,0000,,je možda glavni razlog
Dialogue: 0,0:10:19.98,0:10:22.29,Default,,0000,0000,0000,,što san postoji.
Dialogue: 0,0:10:22.29,0:10:23.81,Default,,0000,0000,0000,,Vi i ja, mi idemo na spavanje
Dialogue: 0,0:10:23.81,0:10:25.54,Default,,0000,0000,0000,,svako veče,
Dialogue: 0,0:10:25.54,0:10:28.55,Default,,0000,0000,0000,,ali naš mozak se nikada ne odmara.
Dialogue: 0,0:10:28.55,0:10:30.38,Default,,0000,0000,0000,,Dok naše tijelo miruje
Dialogue: 0,0:10:30.38,0:10:33.45,Default,,0000,0000,0000,,i naš um hoda u snovima,
Dialogue: 0,0:10:33.45,0:10:35.13,Default,,0000,0000,0000,,elegantna mašinerija našeg mozga
Dialogue: 0,0:10:35.13,0:10:37.11,Default,,0000,0000,0000,,marljivo radi svoj posao,
Dialogue: 0,0:10:37.11,0:10:39.30,Default,,0000,0000,0000,,čisti i održava
Dialogue: 0,0:10:39.30,0:10:42.14,Default,,0000,0000,0000,,ovu nevjerovatno složenu mašinu.
Dialogue: 0,0:10:42.14,0:10:43.18,Default,,0000,0000,0000,,Kao i kućanski posao,
Dialogue: 0,0:10:43.18,0:10:45.92,Default,,0000,0000,0000,,to je prljav i nezahvalan posao,
Dialogue: 0,0:10:45.92,0:10:48.18,Default,,0000,0000,0000,,ali je isto jako bitan.
Dialogue: 0,0:10:48.18,0:10:50.58,Default,,0000,0000,0000,,Ako prestanete da čistite kuhinju
Dialogue: 0,0:10:50.58,0:10:52.49,Default,,0000,0000,0000,,na jedan mjesec
Dialogue: 0,0:10:52.49,0:10:54.93,Default,,0000,0000,0000,,vaša kuća vrlo brzo neće imati
Dialogue: 0,0:10:54.93,0:10:56.54,Default,,0000,0000,0000,,uslove za život.
Dialogue: 0,0:10:56.54,0:10:58.62,Default,,0000,0000,0000,,Ali u mozgu, posljedice neuspjeha
Dialogue: 0,0:10:58.62,0:11:01.56,Default,,0000,0000,0000,,mogu biti mnogo ozbiljnije
Dialogue: 0,0:11:01.56,0:11:04.28,Default,,0000,0000,0000,,od nelagode uzrokovane\Nprašnjavim kredencima,
Dialogue: 0,0:11:04.28,0:11:06.85,Default,,0000,0000,0000,,jer kada je u pitanju mozak
Dialogue: 0,0:11:06.85,0:11:09.22,Default,,0000,0000,0000,,zdravlje i funkcija
Dialogue: 0,0:11:09.22,0:11:12.17,Default,,0000,0000,0000,,uma i tijela je na kocki
Dialogue: 0,0:11:12.17,0:11:14.41,Default,,0000,0000,0000,,i zbog toga, shvatanje ovih
Dialogue: 0,0:11:14.41,0:11:18.68,Default,,0000,0000,0000,,osnovnih funkcija čišćenja našeg mozga\Ndanas
Dialogue: 0,0:11:18.68,0:11:21.68,Default,,0000,0000,0000,,možda je od presudne važnosti\Nza prevenciju i liječenje
Dialogue: 0,0:11:21.68,0:11:24.70,Default,,0000,0000,0000,,bolesti uma sutra.
Dialogue: 0,0:11:24.70,0:11:26.75,Default,,0000,0000,0000,,Hvala.